Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats
المؤلفون المشاركون
Randriamboavonjy, Joseph Iharinjaka
Pacaud, Pierre
Loirand, Gervaise
Tesse, Angela
Heurtebise, Sandrine
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO⋅ bioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular rigidity, and tone impairment.
Moringa oleifera (MOI) is a little tree, and different parts of which are used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including cardiovascular disease.
The present study is aimed at assessing the effect of MOI on aging-associated alteration of the endothelial function in Wistar rats.
Middle-aged Wistar rats (46-week-old males) have been fed with food containing or not 750 mg/kg/day of MOI seed powder for 4 weeks.
A group of young Wistar rats (16-week-old) was used as control.
Measurement of isometric contraction, western blot analysis, and immunostaining has then been performed in the aortas and mesenteric arteries to assess the endothelium function.
MOI treatment improved carbachol-induced relaxation in both aortas and mesenteric arteries of middle-aged rats.
In the aortas, this was associated with an increased Akt signalling and endothelial NO synthase activation and a downregulation of arginase-1.
In the mesenteric arteries, the improvement of the endothelial-dependent relaxation was related to an EDHF-dependent mechanism.
These results suggest a vascular protective effect of MOI seeds against the vascular dysfunction that develops during aging through different mechanisms in conductance and resistance arteries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Randriamboavonjy, Joseph Iharinjaka& Heurtebise, Sandrine& Pacaud, Pierre& Loirand, Gervaise& Tesse, Angela. 2019. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Randriamboavonjy, Joseph Iharinjaka…[et al.]. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Randriamboavonjy, Joseph Iharinjaka& Heurtebise, Sandrine& Pacaud, Pierre& Loirand, Gervaise& Tesse, Angela. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر