Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats
Joint Authors
Randriamboavonjy, Joseph Iharinjaka
Pacaud, Pierre
Loirand, Gervaise
Tesse, Angela
Heurtebise, Sandrine
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO⋅ bioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular rigidity, and tone impairment.
Moringa oleifera (MOI) is a little tree, and different parts of which are used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including cardiovascular disease.
The present study is aimed at assessing the effect of MOI on aging-associated alteration of the endothelial function in Wistar rats.
Middle-aged Wistar rats (46-week-old males) have been fed with food containing or not 750 mg/kg/day of MOI seed powder for 4 weeks.
A group of young Wistar rats (16-week-old) was used as control.
Measurement of isometric contraction, western blot analysis, and immunostaining has then been performed in the aortas and mesenteric arteries to assess the endothelium function.
MOI treatment improved carbachol-induced relaxation in both aortas and mesenteric arteries of middle-aged rats.
In the aortas, this was associated with an increased Akt signalling and endothelial NO synthase activation and a downregulation of arginase-1.
In the mesenteric arteries, the improvement of the endothelial-dependent relaxation was related to an EDHF-dependent mechanism.
These results suggest a vascular protective effect of MOI seeds against the vascular dysfunction that develops during aging through different mechanisms in conductance and resistance arteries.
American Psychological Association (APA)
Randriamboavonjy, Joseph Iharinjaka& Heurtebise, Sandrine& Pacaud, Pierre& Loirand, Gervaise& Tesse, Angela. 2019. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
Modern Language Association (MLA)
Randriamboavonjy, Joseph Iharinjaka…[et al.]. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
American Medical Association (AMA)
Randriamboavonjy, Joseph Iharinjaka& Heurtebise, Sandrine& Pacaud, Pierre& Loirand, Gervaise& Tesse, Angela. Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1202773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202773