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Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice
المؤلفون المشاركون
Liu, Xiaoyan
Zhang, Ruihua
Huang, Lianghu
Zheng, Zihan
Vlassara, Helen
Striker, Gary
Zhang, Xiaoyan
Guan, Youfei
Zheng, Feng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The aged kidney is susceptible to acute injury due presumably to its decreased ability to handle additional challenges, such as endoplasmic reticulum (ER) stress.
This was tested by giving tunicamycin, an ER stress inducer, to either old or young mice.
Injection of high dose caused renal failure in old mice, not in young mice.
Moreover, injection of low dose resulted in severe renal damage in old mice, confirming the increased susceptibility of aged kidney to ER stress.
There existed an abnormality in ER stress response kinetics in aged kidney, characterized by a loss of XBP-1 splicing and decreased PERK-eIF2α phosphorylation at late time point.
The presence of excessive oxidative stress in aged kidney may play a role since high levels of oxidation increased ER stress-induced cell death and decreased IRE1 levels and XBP-1 splicing.
Importantly, treatment with antioxidants protected old mice from kidney injury and normalized IRE1 and XBP-1 responses.
Furthermore, older mice (6 months old) transgenic with antioxidative stress AGER1 were protected from ER stress-induced kidney injury.
In conclusion, the decreased ability to handle ER stress, partly due to the presence of excessive oxidative stress, may contribute to increased susceptibility of the aging kidney to acute injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xiaoyan& Zhang, Ruihua& Huang, Lianghu& Zheng, Zihan& Vlassara, Helen& Striker, Gary…[et al.]. 2019. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xiaoyan…[et al.]. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xiaoyan& Zhang, Ruihua& Huang, Lianghu& Zheng, Zihan& Vlassara, Helen& Striker, Gary…[et al.]. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202902
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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