Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice
Joint Authors
Liu, Xiaoyan
Zhang, Ruihua
Huang, Lianghu
Zheng, Zihan
Vlassara, Helen
Striker, Gary
Zhang, Xiaoyan
Guan, Youfei
Zheng, Feng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The aged kidney is susceptible to acute injury due presumably to its decreased ability to handle additional challenges, such as endoplasmic reticulum (ER) stress.
This was tested by giving tunicamycin, an ER stress inducer, to either old or young mice.
Injection of high dose caused renal failure in old mice, not in young mice.
Moreover, injection of low dose resulted in severe renal damage in old mice, confirming the increased susceptibility of aged kidney to ER stress.
There existed an abnormality in ER stress response kinetics in aged kidney, characterized by a loss of XBP-1 splicing and decreased PERK-eIF2α phosphorylation at late time point.
The presence of excessive oxidative stress in aged kidney may play a role since high levels of oxidation increased ER stress-induced cell death and decreased IRE1 levels and XBP-1 splicing.
Importantly, treatment with antioxidants protected old mice from kidney injury and normalized IRE1 and XBP-1 responses.
Furthermore, older mice (6 months old) transgenic with antioxidative stress AGER1 were protected from ER stress-induced kidney injury.
In conclusion, the decreased ability to handle ER stress, partly due to the presence of excessive oxidative stress, may contribute to increased susceptibility of the aging kidney to acute injury.
American Psychological Association (APA)
Liu, Xiaoyan& Zhang, Ruihua& Huang, Lianghu& Zheng, Zihan& Vlassara, Helen& Striker, Gary…[et al.]. 2019. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
Modern Language Association (MLA)
Liu, Xiaoyan…[et al.]. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
American Medical Association (AMA)
Liu, Xiaoyan& Zhang, Ruihua& Huang, Lianghu& Zheng, Zihan& Vlassara, Helen& Striker, Gary…[et al.]. Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202902