Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms

المؤلفون المشاركون

Jiang, Xin
Wang, Huanhuan
Xin, Ying
Wei, Jinlong
Wang, Bin
Meng, Lingbin
Zhao, Qin
Li, Xinyu

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-12

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects.

Severe radiation-induced normal tissue damage (RINTD) frequently has a significant influence on the progress of RT and the survival and prognosis of patients.

The redox system has been shown to play an important role in the early and late effects of RINTD.

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the main sources of RINTD.

The free radicals produced by irradiation can upregulate several enzymes including nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), lipoxygenases (LOXs), nitric oxide synthase (NOS), and cyclooxygenases (COXs).

These enzymes are expressed in distinct ways in various cells, tissues, and organs and participate in the RINTD process through different regulatory mechanisms.

In recent years, several studies have demonstrated that epigenetic modulators play an important role in the RINTD process.

Epigenetic modifications primarily contain noncoding RNA regulation, histone modifications, and DNA methylation.

In this article, we will review the role of oxidative stress and epigenetic mechanisms in radiation damage, and explore possible prophylactic and therapeutic strategies for RINTD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wei, Jinlong& Wang, Bin& Wang, Huanhuan& Meng, Lingbin& Zhao, Qin& Li, Xinyu…[et al.]. 2019. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203036

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wei, Jinlong…[et al.]. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1203036

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wei, Jinlong& Wang, Bin& Wang, Huanhuan& Meng, Lingbin& Zhao, Qin& Li, Xinyu…[et al.]. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203036

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1203036