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Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
Joint Authors
Jiang, Xin
Wang, Huanhuan
Xin, Ying
Wei, Jinlong
Wang, Bin
Meng, Lingbin
Zhao, Qin
Li, Xinyu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects.
Severe radiation-induced normal tissue damage (RINTD) frequently has a significant influence on the progress of RT and the survival and prognosis of patients.
The redox system has been shown to play an important role in the early and late effects of RINTD.
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the main sources of RINTD.
The free radicals produced by irradiation can upregulate several enzymes including nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), lipoxygenases (LOXs), nitric oxide synthase (NOS), and cyclooxygenases (COXs).
These enzymes are expressed in distinct ways in various cells, tissues, and organs and participate in the RINTD process through different regulatory mechanisms.
In recent years, several studies have demonstrated that epigenetic modulators play an important role in the RINTD process.
Epigenetic modifications primarily contain noncoding RNA regulation, histone modifications, and DNA methylation.
In this article, we will review the role of oxidative stress and epigenetic mechanisms in radiation damage, and explore possible prophylactic and therapeutic strategies for RINTD.
American Psychological Association (APA)
Wei, Jinlong& Wang, Bin& Wang, Huanhuan& Meng, Lingbin& Zhao, Qin& Li, Xinyu…[et al.]. 2019. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203036
Modern Language Association (MLA)
Wei, Jinlong…[et al.]. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1203036
American Medical Association (AMA)
Wei, Jinlong& Wang, Bin& Wang, Huanhuan& Meng, Lingbin& Zhao, Qin& Li, Xinyu…[et al.]. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203036