Bailcalin Protects against Diabetic Cardiomyopathy through Keap1Nrf2AMPK-Mediated Antioxidative and Lipid-Lowering Effects
المؤلفون المشاركون
Wang, Fang
Shan, Yingguang
Li, Ran
Liu, Yuan
Gao, Lu
Qiu, Chun-guang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Previous studies demonstrated that Bailcalin (BAI) prevented cardiac injuries under different disease models.
Whether BAI protected against type 2 diabetes mellitus- (T2DM-) associated cardiomyopathy was investigated in this study.
T2DM was established by the combination of streptozotocin injection and high-fat diet in mice.
BAI was administered daily for 6 months.
After evaluating cardiac functions, mice hearts were removed and processed for morphological, biochemical, and molecular mechanism analyses.
Neonatal rat cardiomyocytes (NRCM) were isolated and treated with high glucose and palmitate (HG/Pal) for in vitro investigation.
BAI significantly ameliorated T2DM-induced cardiomyocyte hypertrophy, interstitial fibrosis, and lipid accumulation accompanied by markedly improved cardiac functions in diabetic mice.
Mechanically, BAI restored decreased phosphorylation of AMPK and enhanced expression and nuclei translocation of Nrf2.
In in vitro experiments, BAI also prevented NRCM from HG/Pal-induced apoptosis and oxidative stress injuries by increasing p-AMPK and Nrf2 accumulation.
The means by which BAI restored p-AMPK seemed to be related to the antioxidative effects of Nrf2 after silencing AMPK or Nrf2 in NRCM.
Furthermore, BAI regulated Nrf2 by inhibiting Nrf2 ubiquitination and consequent degradation mediated by Keap1.
This study showed that BAI alleviated diabetes-associated cardiac dysfunction and cardiomyocyte injuries in vivo and in vitro via Keap1/Nrf2/AMPK-mediated antioxidation and lipid-lowering effects.
BAI might be a potential adjuvant drug for diabetes cardiomyopathy treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ran& Liu, Yuan& Shan, Yingguang& Gao, Lu& Wang, Fang& Qiu, Chun-guang. 2019. Bailcalin Protects against Diabetic Cardiomyopathy through Keap1Nrf2AMPK-Mediated Antioxidative and Lipid-Lowering Effects. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ran…[et al.]. Bailcalin Protects against Diabetic Cardiomyopathy through Keap1Nrf2AMPK-Mediated Antioxidative and Lipid-Lowering Effects. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1203154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ran& Liu, Yuan& Shan, Yingguang& Gao, Lu& Wang, Fang& Qiu, Chun-guang. Bailcalin Protects against Diabetic Cardiomyopathy through Keap1Nrf2AMPK-Mediated Antioxidative and Lipid-Lowering Effects. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر