Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally
المؤلفون المشاركون
da Matta, Sérgio Luiz Pinto
Melo, Fabiana C. S. A.
Oliveira, Juraci A.
Mouro, Viviane G. S.
Martins, Ana L. P.
Silva, Janaina
Menezes, Tatiana P.
Gomes, Marcos L. M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the literature.
Experimental models often make use of the intraperitoneal route (i.p.), although human intoxication occurs preferentially by the oral route and can be continuous.
However, little is known about the effect of Cd administration routes on the testicular structure.
Thus, this study investigated the testicular impact of Cd exposure comparing both i.p.
and oral routes, both single dose (SD), in addition to the oral route in fractional doses (FD).
Swiss adult male mice received CdCl2 1.5 mg/kg i.p., 30 mg/kg oral SD, and 4.28 mg/kg oral FD for 7 consecutive days.
The Cd bioaccumulation was observed in all routes, mainly in the oral FD route.
The concentrations of testicular Ca and Cu decreased in all animals exposed to Cd, while Zn and Mn decreased only in the i.p.
route.
Testicular SOD activity was reduced in both routes of oral administration, while CAT increased in the i.p.
route, and GST increased in all animals exposed to Cd.
Changes in the tubular parameters and cell viability were observed in both routes of Cd administration but were more intense in the oral route, mainly in the FD.
Serum testosterone concentration was reduced in both routes of oral administration.
Tubular damage, such as the vacuolization of the seminiferous epithelium, germ cell detachment, and seminiferous tubule degeneration, occurred in all groups exposed to Cd.
Therefore, the oral Cd administration presented greater potential to promote testicular damage, mainly when the metal was given in a fractionated way.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mouro, Viviane G. S.& Martins, Ana L. P.& Silva, Janaina& Menezes, Tatiana P.& Gomes, Marcos L. M.& Oliveira, Juraci A.…[et al.]. 2019. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mouro, Viviane G. S.…[et al.]. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mouro, Viviane G. S.& Martins, Ana L. P.& Silva, Janaina& Menezes, Tatiana P.& Gomes, Marcos L. M.& Oliveira, Juraci A.…[et al.]. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر