Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally
Joint Authors
da Matta, Sérgio Luiz Pinto
Melo, Fabiana C. S. A.
Oliveira, Juraci A.
Mouro, Viviane G. S.
Martins, Ana L. P.
Silva, Janaina
Menezes, Tatiana P.
Gomes, Marcos L. M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the literature.
Experimental models often make use of the intraperitoneal route (i.p.), although human intoxication occurs preferentially by the oral route and can be continuous.
However, little is known about the effect of Cd administration routes on the testicular structure.
Thus, this study investigated the testicular impact of Cd exposure comparing both i.p.
and oral routes, both single dose (SD), in addition to the oral route in fractional doses (FD).
Swiss adult male mice received CdCl2 1.5 mg/kg i.p., 30 mg/kg oral SD, and 4.28 mg/kg oral FD for 7 consecutive days.
The Cd bioaccumulation was observed in all routes, mainly in the oral FD route.
The concentrations of testicular Ca and Cu decreased in all animals exposed to Cd, while Zn and Mn decreased only in the i.p.
route.
Testicular SOD activity was reduced in both routes of oral administration, while CAT increased in the i.p.
route, and GST increased in all animals exposed to Cd.
Changes in the tubular parameters and cell viability were observed in both routes of Cd administration but were more intense in the oral route, mainly in the FD.
Serum testosterone concentration was reduced in both routes of oral administration.
Tubular damage, such as the vacuolization of the seminiferous epithelium, germ cell detachment, and seminiferous tubule degeneration, occurred in all groups exposed to Cd.
Therefore, the oral Cd administration presented greater potential to promote testicular damage, mainly when the metal was given in a fractionated way.
American Psychological Association (APA)
Mouro, Viviane G. S.& Martins, Ana L. P.& Silva, Janaina& Menezes, Tatiana P.& Gomes, Marcos L. M.& Oliveira, Juraci A.…[et al.]. 2019. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
Modern Language Association (MLA)
Mouro, Viviane G. S.…[et al.]. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
American Medical Association (AMA)
Mouro, Viviane G. S.& Martins, Ana L. P.& Silva, Janaina& Menezes, Tatiana P.& Gomes, Marcos L. M.& Oliveira, Juraci A.…[et al.]. Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1203216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203216