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Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury
المؤلفون المشاركون
Yao, Jihong
Lv, Li
Fu, Rong
Zhou, Junjun
Wang, Ruiwen
Sun, Ruimin
Feng, Dongcheng
Wang, Zhecheng
Zhao, Yan
Tian, Xiaofeng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Alcohol abuse has become common worldwide and has been recognized as a major cause of chronic alcoholic liver disease (ALD).
ALD encompasses a complex process that includes a broad scope of hepatic lesions, ranging from steatosis to cirrhosis.
In particular, reactive oxygen species (ROS) are mainly involved.
Numerous studies have shown that p66shc plays a significant role in ALD.
Protocatechuic acid (PCA), a dihydroxybenzoic acid that is naturally found in green tea, vegetables, and fruits, has efficient free radical scavenging effects.
In this study, we aimed to assess the protective effect of PCA on ALD and to evaluate the microRNA- (miRNA-) p66shc-mediated reduction of ROS formation in ALD.
Our results demonstrated that PCA treatment significantly decreased p66shc expression and downstream ROS formation in ALD.
miR-219a-5p, which was identified by bioinformatics and experimental analysis, was enhanced by PCA and subsequently suppressed p66shc expression.
Importantly, p66shc played an essential role in the protection of PCA-stimulated miR-219a-5p overexpression.
Overall, these findings show that PCA-stimulated miR-219a-5p expression mitigates ALD by reducing p66shc-mediated ROS formation.
This study may contribute to the development of therapeutic interventions for ALD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Rong& Zhou, Junjun& Wang, Ruiwen& Sun, Ruimin& Feng, Dongcheng& Wang, Zhecheng…[et al.]. 2019. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Rong…[et al.]. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Rong& Zhou, Junjun& Wang, Ruiwen& Sun, Ruimin& Feng, Dongcheng& Wang, Zhecheng…[et al.]. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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