Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury
Joint Authors
Yao, Jihong
Lv, Li
Fu, Rong
Zhou, Junjun
Wang, Ruiwen
Sun, Ruimin
Feng, Dongcheng
Wang, Zhecheng
Zhao, Yan
Tian, Xiaofeng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Alcohol abuse has become common worldwide and has been recognized as a major cause of chronic alcoholic liver disease (ALD).
ALD encompasses a complex process that includes a broad scope of hepatic lesions, ranging from steatosis to cirrhosis.
In particular, reactive oxygen species (ROS) are mainly involved.
Numerous studies have shown that p66shc plays a significant role in ALD.
Protocatechuic acid (PCA), a dihydroxybenzoic acid that is naturally found in green tea, vegetables, and fruits, has efficient free radical scavenging effects.
In this study, we aimed to assess the protective effect of PCA on ALD and to evaluate the microRNA- (miRNA-) p66shc-mediated reduction of ROS formation in ALD.
Our results demonstrated that PCA treatment significantly decreased p66shc expression and downstream ROS formation in ALD.
miR-219a-5p, which was identified by bioinformatics and experimental analysis, was enhanced by PCA and subsequently suppressed p66shc expression.
Importantly, p66shc played an essential role in the protection of PCA-stimulated miR-219a-5p overexpression.
Overall, these findings show that PCA-stimulated miR-219a-5p expression mitigates ALD by reducing p66shc-mediated ROS formation.
This study may contribute to the development of therapeutic interventions for ALD.
American Psychological Association (APA)
Fu, Rong& Zhou, Junjun& Wang, Ruiwen& Sun, Ruimin& Feng, Dongcheng& Wang, Zhecheng…[et al.]. 2019. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
Modern Language Association (MLA)
Fu, Rong…[et al.]. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
American Medical Association (AMA)
Fu, Rong& Zhou, Junjun& Wang, Ruiwen& Sun, Ruimin& Feng, Dongcheng& Wang, Zhecheng…[et al.]. Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1203267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203267