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A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis
المؤلفون المشاركون
Zivkovic, Aleksandar R.
Schmidt, Karsten
Sigl, Annette
Decker, Sebastian O.
Weigand, Markus Alexander
Zirnstein, Anne C.
Hofer, Stefan
Brenner, Thorsten
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Early sepsis identification is of paramount importance for an effective therapy and the patient outcome; however, a suitable prognostic biomarker is lacking.
Anti-inflammatory nonneuronal cholinergic signaling modulates the magnitude of an immune response.
Serum cholinesterase (BChE), an enzyme that hydrolyzes acetylcholine, plays an important role during inflammatory response and serves as an accurate index of cholinergic activity.
BChE activity was measured in septic patients using a point-of-care system, and levels of conventional inflammatory markers and the disease severity scores were obtained.
We observed a strong, sustained reduction in BChE activity in patients who died within a 90-day observation period, as compared to survivors.
Reduced BChE activity when measured at the ICU admission effectively differentiated between the 90-day survivor and the nonsurvivor patient groups.
We estimated a critical BChE level of 1.661 kU/L (CI 0.5–0.8, 94% sensitivity, 48% specificity, AUC 0.7) to best predict patient outcome providing a benchmark criterion for early detection of potentially fatal sepsis measured at the admission.
This finding suggests that the BChE activity, used in combination with the laboratory tests, clinical examination, and the disease severity scoring, could serve to identify high-risk patients at the ICU admission, the most critical time point in the sepsis treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zivkovic, Aleksandar R.& Decker, Sebastian O.& Zirnstein, Anne C.& Sigl, Annette& Schmidt, Karsten& Weigand, Markus Alexander…[et al.]. 2018. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zivkovic, Aleksandar R.…[et al.]. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zivkovic, Aleksandar R.& Decker, Sebastian O.& Zirnstein, Anne C.& Sigl, Annette& Schmidt, Karsten& Weigand, Markus Alexander…[et al.]. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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