A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis
Joint Authors
Zivkovic, Aleksandar R.
Schmidt, Karsten
Sigl, Annette
Decker, Sebastian O.
Weigand, Markus Alexander
Zirnstein, Anne C.
Hofer, Stefan
Brenner, Thorsten
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Early sepsis identification is of paramount importance for an effective therapy and the patient outcome; however, a suitable prognostic biomarker is lacking.
Anti-inflammatory nonneuronal cholinergic signaling modulates the magnitude of an immune response.
Serum cholinesterase (BChE), an enzyme that hydrolyzes acetylcholine, plays an important role during inflammatory response and serves as an accurate index of cholinergic activity.
BChE activity was measured in septic patients using a point-of-care system, and levels of conventional inflammatory markers and the disease severity scores were obtained.
We observed a strong, sustained reduction in BChE activity in patients who died within a 90-day observation period, as compared to survivors.
Reduced BChE activity when measured at the ICU admission effectively differentiated between the 90-day survivor and the nonsurvivor patient groups.
We estimated a critical BChE level of 1.661 kU/L (CI 0.5–0.8, 94% sensitivity, 48% specificity, AUC 0.7) to best predict patient outcome providing a benchmark criterion for early detection of potentially fatal sepsis measured at the admission.
This finding suggests that the BChE activity, used in combination with the laboratory tests, clinical examination, and the disease severity scoring, could serve to identify high-risk patients at the ICU admission, the most critical time point in the sepsis treatment.
American Psychological Association (APA)
Zivkovic, Aleksandar R.& Decker, Sebastian O.& Zirnstein, Anne C.& Sigl, Annette& Schmidt, Karsten& Weigand, Markus Alexander…[et al.]. 2018. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
Modern Language Association (MLA)
Zivkovic, Aleksandar R.…[et al.]. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
American Medical Association (AMA)
Zivkovic, Aleksandar R.& Decker, Sebastian O.& Zirnstein, Anne C.& Sigl, Annette& Schmidt, Karsten& Weigand, Markus Alexander…[et al.]. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1203388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203388