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Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
المؤلفون المشاركون
Roca-Agujetas, Vicente
de Dios, Cristina
Lestón, Laura
Marí, Montserrat
Morales, Albert
Colell, Anna
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress.
Autophagy plays a key role during development and adult tissue homeostasis, and growing evidence indicates that this catalytic process also has a direct role in modulating aging.
Although autophagy is essentially protective, depending on the cellular context and stimuli, autophagy outcome can lead to either abnormal cell growth or cell death.
The autophagic process requires a tight regulation, with cellular events following distinct stages and governed by a wide molecular machinery.
Reactive oxygen species (ROS) have been involved in autophagy regulation through multiple signaling pathways, and mitochondria, the main source of endogenous ROS, have emerged as essential signal transducers that mediate autophagy.
In the present review, we aim to summarize the regulatory function of mitochondria in the autophagic process, particularly regarding the mitochondrial role as the coordination node in the autophagy signaling pathway, involving mitochondrial oxidative stress, and their participation as membrane donors in the initial steps of autophagosome assembly.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roca-Agujetas, Vicente& de Dios, Cristina& Lestón, Laura& Marí, Montserrat& Morales, Albert& Colell, Anna. 2019. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roca-Agujetas, Vicente…[et al.]. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roca-Agujetas, Vicente& de Dios, Cristina& Lestón, Laura& Marí, Montserrat& Morales, Albert& Colell, Anna. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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