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Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
Joint Authors
Roca-Agujetas, Vicente
de Dios, Cristina
Lestón, Laura
Marí, Montserrat
Morales, Albert
Colell, Anna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress.
Autophagy plays a key role during development and adult tissue homeostasis, and growing evidence indicates that this catalytic process also has a direct role in modulating aging.
Although autophagy is essentially protective, depending on the cellular context and stimuli, autophagy outcome can lead to either abnormal cell growth or cell death.
The autophagic process requires a tight regulation, with cellular events following distinct stages and governed by a wide molecular machinery.
Reactive oxygen species (ROS) have been involved in autophagy regulation through multiple signaling pathways, and mitochondria, the main source of endogenous ROS, have emerged as essential signal transducers that mediate autophagy.
In the present review, we aim to summarize the regulatory function of mitochondria in the autophagic process, particularly regarding the mitochondrial role as the coordination node in the autophagy signaling pathway, involving mitochondrial oxidative stress, and their participation as membrane donors in the initial steps of autophagosome assembly.
American Psychological Association (APA)
Roca-Agujetas, Vicente& de Dios, Cristina& Lestón, Laura& Marí, Montserrat& Morales, Albert& Colell, Anna. 2019. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
Modern Language Association (MLA)
Roca-Agujetas, Vicente…[et al.]. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
American Medical Association (AMA)
Roca-Agujetas, Vicente& de Dios, Cristina& Lestón, Laura& Marí, Montserrat& Morales, Albert& Colell, Anna. Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203410