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The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
المؤلفون المشاركون
Chen, Chaoran
Xie, Zhenxing
Xia, Shu Fang
Zhou, Xiang
He, Jialiang
Lu, Guangli
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs.
A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications.
γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury.
It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations.
Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far.
Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury.
In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Chaoran& Zhou, Xiang& He, Jialiang& Xie, Zhenxing& Xia, Shu Fang& Lu, Guangli. 2019. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Chaoran…[et al.]. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Chaoran& Zhou, Xiang& He, Jialiang& Xie, Zhenxing& Xia, Shu Fang& Lu, Guangli. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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