The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs
Joint Authors
Chen, Chaoran
Xie, Zhenxing
Xia, Shu Fang
Zhou, Xiang
He, Jialiang
Lu, Guangli
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs.
A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications.
γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury.
It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations.
Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far.
Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury.
In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.
American Psychological Association (APA)
Chen, Chaoran& Zhou, Xiang& He, Jialiang& Xie, Zhenxing& Xia, Shu Fang& Lu, Guangli. 2019. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
Modern Language Association (MLA)
Chen, Chaoran…[et al.]. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
American Medical Association (AMA)
Chen, Chaoran& Zhou, Xiang& He, Jialiang& Xie, Zhenxing& Xia, Shu Fang& Lu, Guangli. The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1203482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203482