Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway
المؤلفون المشاركون
Lin, Zhen-Lang
Cai, Chen-chen
Zhu, Jiang-hu
Ye, Li-xia
Dai, Yuan-yuan
Fang, Ming-chu
Hu, Ying-ying
Pan, Shu-lin
Chen, Si
Li, Pei-jun
Fu, Xiao-qin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-29، 29ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-06
دولة النشر
مصر
عدد الصفحات
29
التخصصات الرئيسية
الملخص EN
Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis.
Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochondria-mediated autophagy dependent on the adenosine monophosphate- (AMP-) activated protein kinase (AMPK) pathway.
Experiments conducted using an in vivo HIE animal model and in vitro hypoxic stress to PC12 cells revealed that intense autophagy associated with mitochondrial function occurred during in vivo HIE injury and in vitro hypoxic stress.
However, glycine treatment effectively attenuated mitochondria-mediated autophagy.
Additionally, after identifying alterations in proteins within the AMPK pathway in rats and PC12 cells following glycine treatment, cyclosporin A (CsA) and 5-aminoimidazole-4-carboxamide-1-b-4-ribofuranoside (AICAR) were administered in these models and indicated that glycine protected against HIE and CoCl2 injury by downregulating mitochondria-mediated autophagy that was dependent on the AMPK pathway.
Overall, glycine attenuated hypoxic-ischemic injury in neurons via reductions in mitochondria-mediated autophagy through the AMPK pathway both in vitro and in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Chen-chen& Zhu, Jiang-hu& Ye, Li-xia& Dai, Yuan-yuan& Fang, Ming-chu& Hu, Ying-ying…[et al.]. 2019. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Chen-chen…[et al.]. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Chen-chen& Zhu, Jiang-hu& Ye, Li-xia& Dai, Yuan-yuan& Fang, Ming-chu& Hu, Ying-ying…[et al.]. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر