Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway
Joint Authors
Lin, Zhen-Lang
Cai, Chen-chen
Zhu, Jiang-hu
Ye, Li-xia
Dai, Yuan-yuan
Fang, Ming-chu
Hu, Ying-ying
Pan, Shu-lin
Chen, Si
Li, Pei-jun
Fu, Xiao-qin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-06
Country of Publication
Egypt
No. of Pages
29
Main Subjects
Abstract EN
Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis.
Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochondria-mediated autophagy dependent on the adenosine monophosphate- (AMP-) activated protein kinase (AMPK) pathway.
Experiments conducted using an in vivo HIE animal model and in vitro hypoxic stress to PC12 cells revealed that intense autophagy associated with mitochondrial function occurred during in vivo HIE injury and in vitro hypoxic stress.
However, glycine treatment effectively attenuated mitochondria-mediated autophagy.
Additionally, after identifying alterations in proteins within the AMPK pathway in rats and PC12 cells following glycine treatment, cyclosporin A (CsA) and 5-aminoimidazole-4-carboxamide-1-b-4-ribofuranoside (AICAR) were administered in these models and indicated that glycine protected against HIE and CoCl2 injury by downregulating mitochondria-mediated autophagy that was dependent on the AMPK pathway.
Overall, glycine attenuated hypoxic-ischemic injury in neurons via reductions in mitochondria-mediated autophagy through the AMPK pathway both in vitro and in vivo.
American Psychological Association (APA)
Cai, Chen-chen& Zhu, Jiang-hu& Ye, Li-xia& Dai, Yuan-yuan& Fang, Ming-chu& Hu, Ying-ying…[et al.]. 2019. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
Modern Language Association (MLA)
Cai, Chen-chen…[et al.]. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
American Medical Association (AMA)
Cai, Chen-chen& Zhu, Jiang-hu& Ye, Li-xia& Dai, Yuan-yuan& Fang, Ming-chu& Hu, Ying-ying…[et al.]. Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1203532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203532