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Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America
المؤلفون المشاركون
Corbett, Carlos E. P.
Laurenti, Márcia Dalastra
Tomokane, Thaise Yumie
Gomes, Claudia Maria de Castro
Araujo Flores, Gabriela Venicia
Sandoval Pacheco, Carmen Maria
Sosa Ochoa, Wilfredo
Zúniga Valeriano, Concepción
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In Honduras, Leishmania (L.) infantum chagasi causes both visceral leishmaniasis (LV) and nonulcerated or atypical cutaneous leishmaniasis (NUCL).
NUCL is characterized by mononuclear inflammatory infiltration of the dermis, composed mainly of lymphocytes followed by macrophages with discrete parasitism.
Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL.
Biopsies (n=20) from human cutaneous nonulcerative lesions were collected and processed by usual histological techniques.
The in situ regulatory immune response was evaluated by immunohistochemistry using antihuman CD4, FoxP3, IL-10, and TGF-β antibodies.
CD4+, FoxP3+, TGF-β+, and IL-10+ cells were observed in the dermis with inflammatory infiltration in all studied cases and at higher densities compared to the normal skin controls.
A positive and strong correlation was observed between CD4+ and FoxP3+ cells, and a positive and moderate correlation was observed between FoxP3+ and TGF-β+ but not with IL-10+ cells.
The data suggest that T regulatory FoxP3+ cells and the regulatory cytokines, especially TGF-β, play an important role in the immunopathogenesis of NUCL, modulating a cellular immune response in the skin, avoiding tissue damage, and leading to low tissue parasitic persistence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Araujo Flores, Gabriela Venicia& Sandoval Pacheco, Carmen Maria& Tomokane, Thaise Yumie& Sosa Ochoa, Wilfredo& Zúniga Valeriano, Concepción& Gomes, Claudia Maria de Castro…[et al.]. 2018. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Araujo Flores, Gabriela Venicia…[et al.]. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Araujo Flores, Gabriela Venicia& Sandoval Pacheco, Carmen Maria& Tomokane, Thaise Yumie& Sosa Ochoa, Wilfredo& Zúniga Valeriano, Concepción& Gomes, Claudia Maria de Castro…[et al.]. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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