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Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America
Joint Authors
Corbett, Carlos E. P.
Laurenti, Márcia Dalastra
Tomokane, Thaise Yumie
Gomes, Claudia Maria de Castro
Araujo Flores, Gabriela Venicia
Sandoval Pacheco, Carmen Maria
Sosa Ochoa, Wilfredo
Zúniga Valeriano, Concepción
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In Honduras, Leishmania (L.) infantum chagasi causes both visceral leishmaniasis (LV) and nonulcerated or atypical cutaneous leishmaniasis (NUCL).
NUCL is characterized by mononuclear inflammatory infiltration of the dermis, composed mainly of lymphocytes followed by macrophages with discrete parasitism.
Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL.
Biopsies (n=20) from human cutaneous nonulcerative lesions were collected and processed by usual histological techniques.
The in situ regulatory immune response was evaluated by immunohistochemistry using antihuman CD4, FoxP3, IL-10, and TGF-β antibodies.
CD4+, FoxP3+, TGF-β+, and IL-10+ cells were observed in the dermis with inflammatory infiltration in all studied cases and at higher densities compared to the normal skin controls.
A positive and strong correlation was observed between CD4+ and FoxP3+ cells, and a positive and moderate correlation was observed between FoxP3+ and TGF-β+ but not with IL-10+ cells.
The data suggest that T regulatory FoxP3+ cells and the regulatory cytokines, especially TGF-β, play an important role in the immunopathogenesis of NUCL, modulating a cellular immune response in the skin, avoiding tissue damage, and leading to low tissue parasitic persistence.
American Psychological Association (APA)
Araujo Flores, Gabriela Venicia& Sandoval Pacheco, Carmen Maria& Tomokane, Thaise Yumie& Sosa Ochoa, Wilfredo& Zúniga Valeriano, Concepción& Gomes, Claudia Maria de Castro…[et al.]. 2018. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
Modern Language Association (MLA)
Araujo Flores, Gabriela Venicia…[et al.]. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
American Medical Association (AMA)
Araujo Flores, Gabriela Venicia& Sandoval Pacheco, Carmen Maria& Tomokane, Thaise Yumie& Sosa Ochoa, Wilfredo& Zúniga Valeriano, Concepción& Gomes, Claudia Maria de Castro…[et al.]. Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203564