Efficiently Capturing Mitochondria-Targeted Constituents with Hepatoprotective Activity from Medicinal Herbs
المؤلفون المشاركون
Yu, Jie
Gu, Wen
Yang, Xingxin
Liang, Li
Li, Feng-Jiao
Liu, Xin
Dong, Jin-Cai
Zeng, Lin-Xi
Mu, Jian-Kang
Bi, Qian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-09
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Targeting mitochondria as a hepatic-protective strategy has gained attention, because of their important roles in energy production, adjustment of apoptosis, and generation of reactive oxygen species.
To promote the discovery of natural mitochondria-targeted hepatic-protectants, we established a hepatocellular mitochondria-based capturing method by coupling affinity ultrafiltration with liquid chromatography/mass spectrometry (LC/MS), which is suitable for identifying mitochondrial ligands from medicinal herbs (MHs).
After evaluating the feasibility of the method, it was applied for capturing mitochondria-targeting constituents from Peucedani Radix extract.
A total of 10 active compounds were identified by LC/MS, all of which were newly identified mitochondrial ligands.
The mitochondria-remedying activity of 4 of the 10 hits was confirmed by pharmacological tests in vitro.
Additionally, the hepatic-protective abilities of 4 hits were verified in both carbon tetrachloride-damaged liver L02 cells and mice.
These results indicated that the method could be used for identifying hepatic mitochondria-targeting constituents in MHs, which might be beneficial for hepatic-protective development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xingxin& Liang, Li& Liu, Xin& Li, Feng-Jiao& Dong, Jin-Cai& Mu, Jian-Kang…[et al.]. 2019. Efficiently Capturing Mitochondria-Targeted Constituents with Hepatoprotective Activity from Medicinal Herbs. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1203565
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xingxin…[et al.]. Efficiently Capturing Mitochondria-Targeted Constituents with Hepatoprotective Activity from Medicinal Herbs. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1203565
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xingxin& Liang, Li& Liu, Xin& Li, Feng-Jiao& Dong, Jin-Cai& Mu, Jian-Kang…[et al.]. Efficiently Capturing Mitochondria-Targeted Constituents with Hepatoprotective Activity from Medicinal Herbs. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1203565
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203565
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر