Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory
المؤلفون المشاركون
Li, Zhao
Zhao, Shuang
Zhang, Hai-Lin
Liu, Peng
Liu, Fei-Fei
Guo, Yue-Xian
Wang, Xiu-Li
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The chemotherapeutic agent paclitaxel is widely used for cancer treatment.
Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors.
However, the neural mechanisms underlying paclitaxel-induced impairment of learning and memory remain unclear.
Paclitaxel treatment leads to proinflammatory factor release and neuronal apoptosis.
Thus, we hypothesized that paclitaxel impairs learning and memory function through proinflammatory factor-induced neuronal apoptosis.
Neuronal apoptosis was assessed by TUNEL assay in the hippocampus.
Protein expression levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the hippocampus tissue were analyzed by Western blot assay.
Spatial learning and memory function were determined by using the Morris water maze (MWM) test.
Paclitaxel treatment significantly increased the escape latencies and decreased the number of crossing in the MWM test.
Furthermore, paclitaxel significantly increased the number of TUNEL-positive neurons in the hippocampus.
Also, paclitaxel treatment increased the expression levels of TNF-α and IL-1β in the hippocampus tissue.
In addition, the TNF-α synthesis inhibitor thalidomide significantly attenuated the number of paclitaxel-induced TUNEL-positive neurons in the hippocampus and restored the impaired spatial learning and memory function in paclitaxel-treated rats.
These data suggest that TNF-α is critically involved in the paclitaxel-induced impairment of learning and memory function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Zhao& Zhao, Shuang& Zhang, Hai-Lin& Liu, Peng& Liu, Fei-Fei& Guo, Yue-Xian…[et al.]. 2018. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Zhao…[et al.]. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Zhao& Zhao, Shuang& Zhang, Hai-Lin& Liu, Peng& Liu, Fei-Fei& Guo, Yue-Xian…[et al.]. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر