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Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory
Joint Authors
Li, Zhao
Zhao, Shuang
Zhang, Hai-Lin
Liu, Peng
Liu, Fei-Fei
Guo, Yue-Xian
Wang, Xiu-Li
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The chemotherapeutic agent paclitaxel is widely used for cancer treatment.
Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors.
However, the neural mechanisms underlying paclitaxel-induced impairment of learning and memory remain unclear.
Paclitaxel treatment leads to proinflammatory factor release and neuronal apoptosis.
Thus, we hypothesized that paclitaxel impairs learning and memory function through proinflammatory factor-induced neuronal apoptosis.
Neuronal apoptosis was assessed by TUNEL assay in the hippocampus.
Protein expression levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the hippocampus tissue were analyzed by Western blot assay.
Spatial learning and memory function were determined by using the Morris water maze (MWM) test.
Paclitaxel treatment significantly increased the escape latencies and decreased the number of crossing in the MWM test.
Furthermore, paclitaxel significantly increased the number of TUNEL-positive neurons in the hippocampus.
Also, paclitaxel treatment increased the expression levels of TNF-α and IL-1β in the hippocampus tissue.
In addition, the TNF-α synthesis inhibitor thalidomide significantly attenuated the number of paclitaxel-induced TUNEL-positive neurons in the hippocampus and restored the impaired spatial learning and memory function in paclitaxel-treated rats.
These data suggest that TNF-α is critically involved in the paclitaxel-induced impairment of learning and memory function.
American Psychological Association (APA)
Li, Zhao& Zhao, Shuang& Zhang, Hai-Lin& Liu, Peng& Liu, Fei-Fei& Guo, Yue-Xian…[et al.]. 2018. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
Modern Language Association (MLA)
Li, Zhao…[et al.]. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
American Medical Association (AMA)
Li, Zhao& Zhao, Shuang& Zhang, Hai-Lin& Liu, Peng& Liu, Fei-Fei& Guo, Yue-Xian…[et al.]. Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1203615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203615