Stimulation of Na+K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPKSIRT3PPARγ Signaling Pathway
المؤلفون المشاركون
Bian, Jin-Song
Xiong, Siping
Sun, Hai-Jian
Cao, Lei
Zhu, Mengyuan
Liu, Tengteng
Wu, Zhiyuan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-15
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Activation of the renin-angiotensin system (RAS) contributes to the pathogenesis of cardiovascular diseases.
Sodium potassium ATPase (NKA) expression and activity are often regulated by angiotensin II (Ang II).
This study is aimed at investigating whether DR-Ab, an antibody against 4th extracellular region of NKA, can protect Ang II-induced cardiomyocyte hypertrophy.
Our results showed that Ang II treatment significantly reduced NKA activity and membrane expression.
Pretreatment with DR-Ab preserved cell size in Ang II-induced cardiomyopathy by stabilizing the plasma membrane expression of NKA and restoring its activity.
DR-Ab reduced intracellular ROS generation through inhibition of NADPH oxidase activity and protection of mitochondrial functions in Ang II-treated H9c2 cardiomyocytes.
Pharmacological manipulation and Western blotting analysis demonstrated the cardioprotective effects were mediated by the activation of the AMPK/Sirt-3/PPARγ signaling pathway.
Taken together, our results suggest that dysfunction of NKA is an important mechanism for Ang II-induced cardiomyopathy and DR-Ab may be a novel and promising therapeutic approach to treat cardiomyocyte hypertrophy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiong, Siping& Sun, Hai-Jian& Cao, Lei& Zhu, Mengyuan& Liu, Tengteng& Wu, Zhiyuan…[et al.]. 2019. Stimulation of Na+K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPKSIRT3PPARγ Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiong, Siping…[et al.]. Stimulation of Na+K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPKSIRT3PPARγ Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiong, Siping& Sun, Hai-Jian& Cao, Lei& Zhu, Mengyuan& Liu, Tengteng& Wu, Zhiyuan…[et al.]. Stimulation of Na+K+-ATPase with an Antibody against Its 4th Extracellular Region Attenuates Angiotensin II-Induced H9c2 Cardiomyocyte Hypertrophy via an AMPKSIRT3PPARγ Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر