Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice
المؤلفون المشاركون
Kang, Wenyi
Liu, Zhenhua
Ma, Changyang
Niu, Yingying
Dong, Jing
Jiang, Huimin
Wang, Jinmei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The immunomodulatory effects of Malus halliana flower polysaccharide (MHFP) were investigated in this paper.
The model of immunosuppressive mice was established by cyclophosphamide, which was treated with different dosages of MHFP (600, 400, and 200 mg/kg·d-1).
The results showed that MHFP significantly increased the index of the spleen and thymus and improved the atrophy of immune organs.
MHFP enhanced the ability of carbon clearance and phagocytosis of mononuclear phagocytes in mice.
Meanwhile, MHFP promoted the proliferation of splenic lymphocytes.
MHFP could enhance the content of serum hemolysin and improve the decrease of hemolysin induced by cyclophosphamide.
The contents of ACP and LDH in the serum and spleen were determined, indicating that MHFP could enhance the activity of macrophages.
MHFP promoted the content of cytokines (IL-2, IL-6, TNF-α, and IFN-γ) and mRNA expression.
At the same time, the pathological changes of the spleen tissue also showed that MHFP could improve the immunosuppression induced by cyclophosphamide.
In addition, MHFP increased the content of SOD, T-AOC, and CAT in the serum and spleen tissue, decreased the level of MDA, and improved the oxidative stress caused by cyclophosphamide.
In conclusion, MHFP could effectively improve the immunosuppression and oxidative stress induced by cyclophosphamide and enhance the immune capacity of mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niu, Yingying& Dong, Jing& Jiang, Huimin& Wang, Jinmei& Liu, Zhenhua& Ma, Changyang…[et al.]. 2020. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niu, Yingying…[et al.]. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niu, Yingying& Dong, Jing& Jiang, Huimin& Wang, Jinmei& Liu, Zhenhua& Ma, Changyang…[et al.]. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر