Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice
Joint Authors
Kang, Wenyi
Liu, Zhenhua
Ma, Changyang
Niu, Yingying
Dong, Jing
Jiang, Huimin
Wang, Jinmei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The immunomodulatory effects of Malus halliana flower polysaccharide (MHFP) were investigated in this paper.
The model of immunosuppressive mice was established by cyclophosphamide, which was treated with different dosages of MHFP (600, 400, and 200 mg/kg·d-1).
The results showed that MHFP significantly increased the index of the spleen and thymus and improved the atrophy of immune organs.
MHFP enhanced the ability of carbon clearance and phagocytosis of mononuclear phagocytes in mice.
Meanwhile, MHFP promoted the proliferation of splenic lymphocytes.
MHFP could enhance the content of serum hemolysin and improve the decrease of hemolysin induced by cyclophosphamide.
The contents of ACP and LDH in the serum and spleen were determined, indicating that MHFP could enhance the activity of macrophages.
MHFP promoted the content of cytokines (IL-2, IL-6, TNF-α, and IFN-γ) and mRNA expression.
At the same time, the pathological changes of the spleen tissue also showed that MHFP could improve the immunosuppression induced by cyclophosphamide.
In addition, MHFP increased the content of SOD, T-AOC, and CAT in the serum and spleen tissue, decreased the level of MDA, and improved the oxidative stress caused by cyclophosphamide.
In conclusion, MHFP could effectively improve the immunosuppression and oxidative stress induced by cyclophosphamide and enhance the immune capacity of mice.
American Psychological Association (APA)
Niu, Yingying& Dong, Jing& Jiang, Huimin& Wang, Jinmei& Liu, Zhenhua& Ma, Changyang…[et al.]. 2020. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
Modern Language Association (MLA)
Niu, Yingying…[et al.]. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
American Medical Association (AMA)
Niu, Yingying& Dong, Jing& Jiang, Huimin& Wang, Jinmei& Liu, Zhenhua& Ma, Changyang…[et al.]. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203761