Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway
المؤلفون المشاركون
Mahmoud, Ayman M.
Hussein, Omnia E.
Hassanein, Emad H. M.
Sayed, Ahmed M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-25، 25ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-25
دولة النشر
مصر
عدد الصفحات
25
التخصصات الرئيسية
الملخص EN
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases.
Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes.
Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-κB.
Therefore, pharmacological activation of Nrf2 is a promising therapeutic strategy for the treatment/prevention of several diseases that are underlined by both oxidative stress and inflammation.
Coumarins are natural products with promising pharmacological activities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory efficacies.
Coumarins are found in many plants, fungi, and bacteria and have been widely used as complementary and alternative medicines.
Some coumarins have shown an ability to activate Nrf2 signaling in different cells and animal models.
The present review compiles the research findings of seventeen coumarin derivatives of plant origin (imperatorin, visnagin, urolithin B, urolithin A, scopoletin, esculin, esculetin, umbelliferone, fraxetin, fraxin, daphnetin, anomalin, wedelolactone, glycycoumarin, osthole, hydrangenol, and isoimperatorin) as antioxidant and anti-inflammatory agents, emphasizing the role of Nrf2 activation in their pharmacological activities.
Additionally, molecular docking simulations were utilized to investigate the potential binding mode of these coumarins with Keap1 as a strategy to disrupt Keap1/Nrf2 protein-protein interaction and activate Nrf2 signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassanein, Emad H. M.& Sayed, Ahmed M.& Hussein, Omnia E.& Mahmoud, Ayman M.. 2020. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassanein, Emad H. M.…[et al.]. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassanein, Emad H. M.& Sayed, Ahmed M.& Hussein, Omnia E.& Mahmoud, Ayman M.. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203785
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر