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Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway
Joint Authors
Mahmoud, Ayman M.
Hussein, Omnia E.
Hassanein, Emad H. M.
Sayed, Ahmed M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases.
Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes.
Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-κB.
Therefore, pharmacological activation of Nrf2 is a promising therapeutic strategy for the treatment/prevention of several diseases that are underlined by both oxidative stress and inflammation.
Coumarins are natural products with promising pharmacological activities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory efficacies.
Coumarins are found in many plants, fungi, and bacteria and have been widely used as complementary and alternative medicines.
Some coumarins have shown an ability to activate Nrf2 signaling in different cells and animal models.
The present review compiles the research findings of seventeen coumarin derivatives of plant origin (imperatorin, visnagin, urolithin B, urolithin A, scopoletin, esculin, esculetin, umbelliferone, fraxetin, fraxin, daphnetin, anomalin, wedelolactone, glycycoumarin, osthole, hydrangenol, and isoimperatorin) as antioxidant and anti-inflammatory agents, emphasizing the role of Nrf2 activation in their pharmacological activities.
Additionally, molecular docking simulations were utilized to investigate the potential binding mode of these coumarins with Keap1 as a strategy to disrupt Keap1/Nrf2 protein-protein interaction and activate Nrf2 signaling.
American Psychological Association (APA)
Hassanein, Emad H. M.& Sayed, Ahmed M.& Hussein, Omnia E.& Mahmoud, Ayman M.. 2020. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
Modern Language Association (MLA)
Hassanein, Emad H. M.…[et al.]. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
American Medical Association (AMA)
Hassanein, Emad H. M.& Sayed, Ahmed M.& Hussein, Omnia E.& Mahmoud, Ayman M.. Coumarins as Modulators of the Keap1Nrf2ARE Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1203785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203785