Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation
المؤلفون المشاركون
Wu, Wencan
Qian, Jianchang
Liang, Guang
Ju, Xin
Jin, Yiyi
Bao, Xiaodong
Li, Li
Zheng, Suqing
Chen, Xiong
Xiao, Zhongxiang
Chen, Xuemei
Zhu, Weiwei
Li, Weixin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Inflammation is a key factor in the pathogenesis of ALI.
Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury.
Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood.
In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI.
Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB.
Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression.
In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation.
These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Yiyi& Qian, Jianchang& Ju, Xin& Bao, Xiaodong& Li, Li& Zheng, Suqing…[et al.]. 2018. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Yiyi…[et al.]. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Yiyi& Qian, Jianchang& Ju, Xin& Bao, Xiaodong& Li, Li& Zheng, Suqing…[et al.]. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203836
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر