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Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation
Joint Authors
Wu, Wencan
Qian, Jianchang
Liang, Guang
Ju, Xin
Jin, Yiyi
Bao, Xiaodong
Li, Li
Zheng, Suqing
Chen, Xiong
Xiao, Zhongxiang
Chen, Xuemei
Zhu, Weiwei
Li, Weixin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Inflammation is a key factor in the pathogenesis of ALI.
Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury.
Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood.
In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI.
Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB.
Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression.
In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation.
These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.
American Psychological Association (APA)
Jin, Yiyi& Qian, Jianchang& Ju, Xin& Bao, Xiaodong& Li, Li& Zheng, Suqing…[et al.]. 2018. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
Modern Language Association (MLA)
Jin, Yiyi…[et al.]. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
American Medical Association (AMA)
Jin, Yiyi& Qian, Jianchang& Ju, Xin& Bao, Xiaodong& Li, Li& Zheng, Suqing…[et al.]. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1203836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203836