Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease and Associated with Atherosclerosis
المؤلفون المشاركون
Hu, Wenjing
Geng, Shan
Xu, Shangcheng
Li, Ke
Yang, Mengliu
Han, Hongdong
Zhou, Baoyong
Fan, Xiaoyun
Yang, Gangyi
Liu, Yongsheng
Liu, Hua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Objectives.
Genome-wide association studies (GWAS) have shown that cartilage intermediate layer protein 2 (CILP2) is associated with blood lipid levels and coronary heart disease (CHD).
However, no study has reported whether CILP2 is related to atherosclerosis in humans.
The purpose of the current study is to identify the associations between CILP2 and atherosclerosis in vitro and in vivo.
Methods and Results.
Circulating CILP2 levels (measured by ELISA) were compared to various insulin resistance- and atherosclerosis-related parameters in normal subjects and newly diagnosed CHD patients.
THP-1 cells were cultured and treated with indicated stimulators.
Western blots and RT-PCR were performed to examine protein and mRNA expressions.
The results showed that there were significantly higher circulating CILP2 levels in CHD patients relative to healthy controls.
Circulating CILP2 correlated positively with waist-hip ratio (WHR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), HbA1c, homeostasis model assessment of insulin resistance (HOMA-IR), and Gensini scores.
In an in vitro study, we found that CILP2 increased oxidatively modified LDL-stimulated lipid accumulation in THP-1 macrophages via the upregulation of CD36 expression.
Inhibition of PPARγ signaling eliminated the CILP2 regulation of CD36 expression in THP-1 macrophages.
CILP2 positively regulated CD36 transcription through PPARγ-mediated action on two peroxisome-proliferator-responsive elements (PPREs) binding sites of CD36 promoter, PPRE-G, and PPRE-J.
Conclusions.
Our findings have uncovered a novel role for CILP2 in lipid uptake and foam cell formation.
This role is mediated by CD36 through the activation of PPARγ pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Wenjing& Li, Ke& Han, Hongdong& Geng, Shan& Zhou, Baoyong& Fan, Xiaoyun…[et al.]. 2020. Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease and Associated with Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203844
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Wenjing…[et al.]. Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease and Associated with Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1203844
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Wenjing& Li, Ke& Han, Hongdong& Geng, Shan& Zhou, Baoyong& Fan, Xiaoyun…[et al.]. Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease and Associated with Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1203844
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203844
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر