![](/images/graphics-bg.png)
Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway
المؤلفون المشاركون
Zheng, Xiaodong
Chu, Qiang
Jia, Ruoyi
Zhang, Shuang
Chen, Meng
Han, Wen
Chen, Wen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-25
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs.
Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regulatory mechanism on these steps.
Our previous studies indicated that cherry anthocyanins (CACN) protected against high fat diet-induced obesity and NALFD in C57BL/6 mice, while the underlying molecule mechanism is still unclear.
Thus, in this study, we show that CACN protect against oleic acid- (OA-) induced oxidative stress and attenuate lipid droplet accumulation in NAFLD cell models.
According to the results of a transmission electron microscope (TEM), western blot, immunofluorescence (IF), and adenovirus transfection (Ad-mCherry-GFP-LC3B), autophagy is in accordance with the lipid-lowering effect induced by CACN.
Further studies illustrate that CACN may activate autophagy via mTOR pathways.
In addition, an autophagy inhibitor, 3-methyladenine (3-MA), was applied and the result suggested that autophagy indeed participates in the lipid clearance process in OA-induced lipid accumulation.
All these results indicate that the positive effects of CACN on OA-induced hepatic lipid accumulation are mediated via activating autophagy, showing a potential target for the therapeutic strategy of NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chu, Qiang& Zhang, Shuang& Chen, Meng& Han, Wen& Jia, Ruoyi& Chen, Wen…[et al.]. 2019. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chu, Qiang…[et al.]. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chu, Qiang& Zhang, Shuang& Chen, Meng& Han, Wen& Jia, Ruoyi& Chen, Wen…[et al.]. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)