![](/images/graphics-bg.png)
Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway
Joint Authors
Zheng, Xiaodong
Chu, Qiang
Jia, Ruoyi
Zhang, Shuang
Chen, Meng
Han, Wen
Chen, Wen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-25
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs.
Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regulatory mechanism on these steps.
Our previous studies indicated that cherry anthocyanins (CACN) protected against high fat diet-induced obesity and NALFD in C57BL/6 mice, while the underlying molecule mechanism is still unclear.
Thus, in this study, we show that CACN protect against oleic acid- (OA-) induced oxidative stress and attenuate lipid droplet accumulation in NAFLD cell models.
According to the results of a transmission electron microscope (TEM), western blot, immunofluorescence (IF), and adenovirus transfection (Ad-mCherry-GFP-LC3B), autophagy is in accordance with the lipid-lowering effect induced by CACN.
Further studies illustrate that CACN may activate autophagy via mTOR pathways.
In addition, an autophagy inhibitor, 3-methyladenine (3-MA), was applied and the result suggested that autophagy indeed participates in the lipid clearance process in OA-induced lipid accumulation.
All these results indicate that the positive effects of CACN on OA-induced hepatic lipid accumulation are mediated via activating autophagy, showing a potential target for the therapeutic strategy of NAFLD.
American Psychological Association (APA)
Chu, Qiang& Zhang, Shuang& Chen, Meng& Han, Wen& Jia, Ruoyi& Chen, Wen…[et al.]. 2019. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
Modern Language Association (MLA)
Chu, Qiang…[et al.]. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
American Medical Association (AMA)
Chu, Qiang& Zhang, Shuang& Chen, Meng& Han, Wen& Jia, Ruoyi& Chen, Wen…[et al.]. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1203847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203847