Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome
المؤلفون المشاركون
Lu, Hung-I
Sheu, Jiunn-Jye
Chen, Yi-Ling
Lin, Kun-Chen
Yin, Tsung-Cheng
Sung, Pei-Hsun
Chen, Kuan-Hung
Chai, Han-Tan
Chen, Chih-Hung
Li, Yi-Chen
Shao, Pei-Lin
Lee, Mel S.
Wallace, Christopher Glenn
Yip, Hon-Kan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS).
ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed application 0.15 mJ/mm2 for 200 impulses at 6 Hz per left/right lung field.
In vitro and ex vivo studies showed that SW enhances mitochondrial uptake into lung epithelial and parenchyma cells (all p<0.001).
Flow cytometry demonstrated that albumin levels and numbers of inflammatory cells (Ly6G+/CD14+/CD68+/CD11b/c+) in bronchoalveolar lavage fluid were the highest in untreated ARDS, were progressively reduced across SW, Mito, and SW + Mito (all p<0.0001), and were the lowest in sham controls.
The same profile was also seen for fibrosis/collagen deposition, levels of biomarkers of oxidative stress (NOX-1/NOX-2/oxidized protein), inflammation (MMP-9/TNF-α/NF-κB/IL-1β/ICAM-1), apoptosis (cleaved caspase 3/PARP), fibrosis (Smad3/TGF-β), mitochondrial damage (cytosolic cytochrome c) (all p<0.0001), and DNA damage (γ-H2AX+), and numbers of parenchymal inflammatory cells (CD11+/CD14+/CD40L+/F4/80+) (p<0.0001).
These results suggest that SW-assisted Mito therapy effectively protects the lung parenchyma from ARDS-induced injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Kun-Chen& Wallace, Christopher Glenn& Yin, Tsung-Cheng& Sung, Pei-Hsun& Chen, Kuan-Hung& Lu, Hung-I…[et al.]. 2018. Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1203881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Kun-Chen…[et al.]. Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome. Mediators of Inflammation No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1203881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Kun-Chen& Wallace, Christopher Glenn& Yin, Tsung-Cheng& Sung, Pei-Hsun& Chen, Kuan-Hung& Lu, Hung-I…[et al.]. Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1203881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر