BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension
المؤلفون المشاركون
Li, Yuehua
Chen, Dan
Zang, Ying-Hao
Qiu, Yun
Zhang, Feng
Chen, Ai-Dong
Wang, Jue-Jin
Chen, Qi
Kang, Yu-Ming
Zhu, Guo-Qing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Proliferation and oxidative stress of vascular smooth muscle cells (VSMCs) contribute to vascular remodeling in hypertension and several major vascular diseases.
B-cell lymphoma 6 (BCL6) functions as a transcriptional repressor.
The present study is designed to determine the roles of BCL6 in VSMC proliferation and oxidative stress and underlying mechanism.
Angiotensin (Ang) II was used to induce VSMC proliferation and oxidative stress in human VSMCs.
Effects of BCL6 overexpression and knockdown were, respectively, investigated in Ang II-treated human VSMCs.
Therapeutical effects of BCL6 overexpression on vascular remodeling, oxidative stress, and proliferation were determined in the aorta of spontaneously hypertensive rats (SHR).
Ang II reduced BCL6 expression in human VSMCs.
BCL6 overexpression attenuated while BCL6 knockdown enhanced the Ang II-induced upregulation of NADPH oxidase 4 (NOX4), production of reactive oxygen species (ROS), and proliferation of VSMCs.
BCL6 expression was downregulated in SHR.
BCL6 overexpression in SHR reduced NOX4 expression, ROS production, and proliferation of the aortic media of SHR.
Moreover, BCL6 overexpression attenuated vascular remodeling and hypertension in SHR.
However, BCL6 overexpression had no significant effects on NOX2 expression in human VSMCs or in SHR.
We conclude that BCL6 attenuates proliferation and oxidative stress of VSMCs in hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Dan& Zang, Ying-Hao& Qiu, Yun& Zhang, Feng& Chen, Ai-Dong& Wang, Jue-Jin…[et al.]. 2019. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Dan…[et al.]. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Dan& Zang, Ying-Hao& Qiu, Yun& Zhang, Feng& Chen, Ai-Dong& Wang, Jue-Jin…[et al.]. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر