BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension
Joint Authors
Li, Yuehua
Chen, Dan
Zang, Ying-Hao
Qiu, Yun
Zhang, Feng
Chen, Ai-Dong
Wang, Jue-Jin
Chen, Qi
Kang, Yu-Ming
Zhu, Guo-Qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Proliferation and oxidative stress of vascular smooth muscle cells (VSMCs) contribute to vascular remodeling in hypertension and several major vascular diseases.
B-cell lymphoma 6 (BCL6) functions as a transcriptional repressor.
The present study is designed to determine the roles of BCL6 in VSMC proliferation and oxidative stress and underlying mechanism.
Angiotensin (Ang) II was used to induce VSMC proliferation and oxidative stress in human VSMCs.
Effects of BCL6 overexpression and knockdown were, respectively, investigated in Ang II-treated human VSMCs.
Therapeutical effects of BCL6 overexpression on vascular remodeling, oxidative stress, and proliferation were determined in the aorta of spontaneously hypertensive rats (SHR).
Ang II reduced BCL6 expression in human VSMCs.
BCL6 overexpression attenuated while BCL6 knockdown enhanced the Ang II-induced upregulation of NADPH oxidase 4 (NOX4), production of reactive oxygen species (ROS), and proliferation of VSMCs.
BCL6 expression was downregulated in SHR.
BCL6 overexpression in SHR reduced NOX4 expression, ROS production, and proliferation of the aortic media of SHR.
Moreover, BCL6 overexpression attenuated vascular remodeling and hypertension in SHR.
However, BCL6 overexpression had no significant effects on NOX2 expression in human VSMCs or in SHR.
We conclude that BCL6 attenuates proliferation and oxidative stress of VSMCs in hypertension.
American Psychological Association (APA)
Chen, Dan& Zang, Ying-Hao& Qiu, Yun& Zhang, Feng& Chen, Ai-Dong& Wang, Jue-Jin…[et al.]. 2019. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
Modern Language Association (MLA)
Chen, Dan…[et al.]. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
American Medical Association (AMA)
Chen, Dan& Zang, Ying-Hao& Qiu, Yun& Zhang, Feng& Chen, Ai-Dong& Wang, Jue-Jin…[et al.]. BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203895