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Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species
المؤلفون المشاركون
He, Ke
Xiang, Guoan
Yu, Honggang
Wu, Lu
Ding, Qianshan
Haider, Farhan
Wang, Haihe
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
At present, apatinib is considered a new generation agent for the treatment of patients with gastric cancer.
However, the effects of apatinib on pancreatic cancer have not been clarified.
This study investigated the impact of apatinib on the biological function of pancreatic cancer cells and the potential mechanism involved in this process.
Using the Cell Counting Kit-8 method, we confirmed that apatinib treatment inhibited cell proliferation in vitro.
Moreover, the migration rate of pancreatic cells was inhibited.
The effects of apatinib on apoptosis and cell cycle distribution of pancreatic carcinoma cells were detected by flow cytometry.
The number of apoptotic cells was significantly increased, and the cell cycle was altered.
Furthermore, we demonstrated that apatinib inhibited the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor, and markers of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway, which increased the levels of reactive oxygen species in vitro.
Apatinib significantly inhibited the biological function of pancreatic cancer cells.
It promoted apoptosis, downregulated the expression of HIF-1α, and increased the levels of reactive oxygen species.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Ke& Wu, Lu& Ding, Qianshan& Haider, Farhan& Yu, Honggang& Wang, Haihe…[et al.]. 2019. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Ke…[et al.]. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Ke& Wu, Lu& Ding, Qianshan& Haider, Farhan& Yu, Honggang& Wang, Haihe…[et al.]. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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