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Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species
Joint Authors
He, Ke
Xiang, Guoan
Yu, Honggang
Wu, Lu
Ding, Qianshan
Haider, Farhan
Wang, Haihe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
At present, apatinib is considered a new generation agent for the treatment of patients with gastric cancer.
However, the effects of apatinib on pancreatic cancer have not been clarified.
This study investigated the impact of apatinib on the biological function of pancreatic cancer cells and the potential mechanism involved in this process.
Using the Cell Counting Kit-8 method, we confirmed that apatinib treatment inhibited cell proliferation in vitro.
Moreover, the migration rate of pancreatic cells was inhibited.
The effects of apatinib on apoptosis and cell cycle distribution of pancreatic carcinoma cells were detected by flow cytometry.
The number of apoptotic cells was significantly increased, and the cell cycle was altered.
Furthermore, we demonstrated that apatinib inhibited the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor, and markers of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway, which increased the levels of reactive oxygen species in vitro.
Apatinib significantly inhibited the biological function of pancreatic cancer cells.
It promoted apoptosis, downregulated the expression of HIF-1α, and increased the levels of reactive oxygen species.
American Psychological Association (APA)
He, Ke& Wu, Lu& Ding, Qianshan& Haider, Farhan& Yu, Honggang& Wang, Haihe…[et al.]. 2019. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
Modern Language Association (MLA)
He, Ke…[et al.]. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
American Medical Association (AMA)
He, Ke& Wu, Lu& Ding, Qianshan& Haider, Farhan& Yu, Honggang& Wang, Haihe…[et al.]. Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1203981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203981