Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure
المؤلفون المشاركون
Hu, Yunzhao
Huang, Yuli
Lv, Wei-biao
Yang, Shaomin
Chen, Haixiong
Tan, Kuan
Cai, Fusheng
Du, Yongxing
Hu, Qiugen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Quantification of extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR) has emerged as a noninvasive diagnostic tool to assess myocardial fibrosis.
Secreted frizzled-related protein 2 (SFRP2) appears to play an important role in cardiac fibrosis.
We aimed to evaluate the association between SFRP2 and myocardial fibrosis and the prognostic value of ECV fraction in patients with heart failure (HF).
Methods.
In this prospective cohort study, 72 hospitalized adult patients (age≥18 years) with severe decompensated HF were included.
CMR measurements and T1 mapping were performed to calculate ECV fraction.
Serum SFRP2 level was detected by an enzyme-linked immunosorbent assay kit.
All patients were followed up, and the primary outcomes were composite events including all-cause mortality and HF hospitalization.
Results.
During the median follow-up of 12 months, 27 (37.5%) patients experienced primary outcome events and had higher levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), SFRP2, and ECV fraction compared with those without events.
In Pearson correlation analysis, levels of SFRP2 (r=0.33), high-sensitivity C-reactive protein (r=0.31), and hemoglobin A1c (r=0.29) were associated with ECV fraction (all P<0.05); however, in multivariate linear regression analysis, SFRP2 was the only significant factor determined for ECV fraction (rpartial=0.33, P=0.02).
In multivariate Cox regression analysis, age (each 10 years, hazard ratio (HR) 1.13, 95% confidence interval (CI) 1.04–1.22), ECV fraction (per doubling, HR 1.68, 95% CI 1.03–2.74), and NT-proBNP (per doubling, HR 2.46, 95% CI 1.05–5.76) were independent risk factors for primary outcomes.
Conclusions.
Higher ECV fraction is associated with worsened prognosis in HF.
SFRP2 is an independent biomarker for myocardial fibrosis.
Further studies are needed to explore the potential therapeutic value of SFRP2 in myocardial fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Shaomin& Chen, Haixiong& Tan, Kuan& Cai, Fusheng& Du, Yongxing& Lv, Wei-biao…[et al.]. 2020. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Shaomin…[et al.]. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Shaomin& Chen, Haixiong& Tan, Kuan& Cai, Fusheng& Du, Yongxing& Lv, Wei-biao…[et al.]. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203996
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر