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Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure
Joint Authors
Hu, Yunzhao
Huang, Yuli
Lv, Wei-biao
Yang, Shaomin
Chen, Haixiong
Tan, Kuan
Cai, Fusheng
Du, Yongxing
Hu, Qiugen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Quantification of extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR) has emerged as a noninvasive diagnostic tool to assess myocardial fibrosis.
Secreted frizzled-related protein 2 (SFRP2) appears to play an important role in cardiac fibrosis.
We aimed to evaluate the association between SFRP2 and myocardial fibrosis and the prognostic value of ECV fraction in patients with heart failure (HF).
Methods.
In this prospective cohort study, 72 hospitalized adult patients (age≥18 years) with severe decompensated HF were included.
CMR measurements and T1 mapping were performed to calculate ECV fraction.
Serum SFRP2 level was detected by an enzyme-linked immunosorbent assay kit.
All patients were followed up, and the primary outcomes were composite events including all-cause mortality and HF hospitalization.
Results.
During the median follow-up of 12 months, 27 (37.5%) patients experienced primary outcome events and had higher levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), SFRP2, and ECV fraction compared with those without events.
In Pearson correlation analysis, levels of SFRP2 (r=0.33), high-sensitivity C-reactive protein (r=0.31), and hemoglobin A1c (r=0.29) were associated with ECV fraction (all P<0.05); however, in multivariate linear regression analysis, SFRP2 was the only significant factor determined for ECV fraction (rpartial=0.33, P=0.02).
In multivariate Cox regression analysis, age (each 10 years, hazard ratio (HR) 1.13, 95% confidence interval (CI) 1.04–1.22), ECV fraction (per doubling, HR 1.68, 95% CI 1.03–2.74), and NT-proBNP (per doubling, HR 2.46, 95% CI 1.05–5.76) were independent risk factors for primary outcomes.
Conclusions.
Higher ECV fraction is associated with worsened prognosis in HF.
SFRP2 is an independent biomarker for myocardial fibrosis.
Further studies are needed to explore the potential therapeutic value of SFRP2 in myocardial fibrosis.
American Psychological Association (APA)
Yang, Shaomin& Chen, Haixiong& Tan, Kuan& Cai, Fusheng& Du, Yongxing& Lv, Wei-biao…[et al.]. 2020. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
Modern Language Association (MLA)
Yang, Shaomin…[et al.]. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
American Medical Association (AMA)
Yang, Shaomin& Chen, Haixiong& Tan, Kuan& Cai, Fusheng& Du, Yongxing& Lv, Wei-biao…[et al.]. Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1203996