Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress
المؤلفون المشاركون
Fan, Bin
Li, Guang-Yu
Zhang, Zi-Yuan
Bao, Xiao-Li
Cong, Yun-Yi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Age-related macular degeneration (AMD) is a leading cause of severe visual loss and irreversible blindness in the elderly population worldwide.
Retinal pigment epithelial (RPE) cells are the major site of pathological alterations in AMD.
They are responsible for the phagocytosis of shed photoreceptor outer segments (POSs) and clearance of cellular waste under physiological conditions.
Age-related, cumulative oxidative stimuli contribute to the pathogenesis of AMD.
Excessive oxidative stress induces RPE cell degeneration and incomplete digestion of POSs, leading to the continuous accumulation of cellular waste (such as lipofuscin).
Autophagy is a major system of degradation of damaged or unnecessary proteins.
However, degenerative RPE cells in AMD patients cannot perform autophagy sufficiently to resist oxidative damage.
Increasing evidence supports the idea that enhancing the autophagic process can properly alleviate oxidative injury in AMD and protect RPE and photoreceptor cells from degeneration and death, although overactivated autophagy may lead to cell death at early stages of retinal degenerative diseases.
The crosstalk among the NFE2L2, PGC-1, p62, AMPK, and PI3K/Akt/mTOR pathways may play a crucial role in improving disturbed autophagy and mitigating the progression of AMD.
In this review, we discuss how autophagy prevents oxidative damage in AMD, summarize potential neuroprotective strategies for therapeutic interventions, and provide an overview of these neuroprotective mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zi-Yuan& Bao, Xiao-Li& Cong, Yun-Yi& Fan, Bin& Li, Guang-Yu. 2020. Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204066
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zi-Yuan…[et al.]. Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204066
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zi-Yuan& Bao, Xiao-Li& Cong, Yun-Yi& Fan, Bin& Li, Guang-Yu. Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204066
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204066
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر