Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer
المؤلفون المشاركون
Panis, Carolina
Herrera, A. C. S. A.
Cecchini, Rubens
Pires, Bruno R. B.
Alves, Vinícius Dias
Binato, Renata
Pizzatti, Luciana
Abdelhay, Eliana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Breast cancer is the leading cause of cancer-associated death among women worldwide.
Its high mortality rate is related to resistance towards chemotherapies, which is one of the major challenges of breast cancer research.
In this study, we used label-free mass spectrometry- (MS-) based proteomics to investigate the differences between circulating proteins in the plasma of patients with chemoresponsive and chemoresistant luminal A breast cancer.
MS analysis revealed 205 differentially expressed proteins.
Furthermore, we used in silico tools to build protein-protein interaction networks.
Most of the upregulated proteins in the chemoresistant group were closely related and tightly linked.
The predominant networks were related to oxidative stress, the inflammatory response, and the complement cascade.
Through this analysis, we identified inflammation and oxidative stress as central processes of breast cancer chemoresistance.
Furthermore, we confirmed our hypothesis by evaluating oxidative stress and performing cytokine profiling in our cohort.
The connections among oxidative stress, inflammation, and the complement system described in our study seem to indicate a pivotal axis in breast cancer chemoresistance.
Hence, these findings will have significant clinical implications for improving therapies to bypass breast cancer chemoresistance in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pires, Bruno R. B.& Panis, Carolina& Alves, Vinícius Dias& Herrera, A. C. S. A.& Binato, Renata& Pizzatti, Luciana…[et al.]. 2019. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pires, Bruno R. B.…[et al.]. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pires, Bruno R. B.& Panis, Carolina& Alves, Vinícius Dias& Herrera, A. C. S. A.& Binato, Renata& Pizzatti, Luciana…[et al.]. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204103
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر