Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer
Joint Authors
Panis, Carolina
Herrera, A. C. S. A.
Cecchini, Rubens
Pires, Bruno R. B.
Alves, Vinícius Dias
Binato, Renata
Pizzatti, Luciana
Abdelhay, Eliana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Breast cancer is the leading cause of cancer-associated death among women worldwide.
Its high mortality rate is related to resistance towards chemotherapies, which is one of the major challenges of breast cancer research.
In this study, we used label-free mass spectrometry- (MS-) based proteomics to investigate the differences between circulating proteins in the plasma of patients with chemoresponsive and chemoresistant luminal A breast cancer.
MS analysis revealed 205 differentially expressed proteins.
Furthermore, we used in silico tools to build protein-protein interaction networks.
Most of the upregulated proteins in the chemoresistant group were closely related and tightly linked.
The predominant networks were related to oxidative stress, the inflammatory response, and the complement cascade.
Through this analysis, we identified inflammation and oxidative stress as central processes of breast cancer chemoresistance.
Furthermore, we confirmed our hypothesis by evaluating oxidative stress and performing cytokine profiling in our cohort.
The connections among oxidative stress, inflammation, and the complement system described in our study seem to indicate a pivotal axis in breast cancer chemoresistance.
Hence, these findings will have significant clinical implications for improving therapies to bypass breast cancer chemoresistance in the future.
American Psychological Association (APA)
Pires, Bruno R. B.& Panis, Carolina& Alves, Vinícius Dias& Herrera, A. C. S. A.& Binato, Renata& Pizzatti, Luciana…[et al.]. 2019. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
Modern Language Association (MLA)
Pires, Bruno R. B.…[et al.]. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
American Medical Association (AMA)
Pires, Bruno R. B.& Panis, Carolina& Alves, Vinícius Dias& Herrera, A. C. S. A.& Binato, Renata& Pizzatti, Luciana…[et al.]. Label-Free Proteomics Revealed Oxidative Stress and Inflammation as Factors That Enhance Chemoresistance in Luminal Breast Cancer. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1204103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204103