Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring
المؤلفون المشاركون
Sizzano, Federico
Collino, Sebastiano
Cominetti, Ornella
Ostan, Rita
Palini, Alessio
Monti, Daniela
Garagnani, Paolo
Mari, Daniela
Franceschi, Claudio
Bacalini, Maria Giulia
Pirazzini, Chiara
Passarino, Giuseppe
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The production of reactive oxygen species (ROS) may promote immunosenescence if not counterbalanced by the antioxidant systems.
Cell membranes, proteins, and nucleic acids become the target of ROS and progressively lose their structure and functions.
This process could lead to an impairment of the immune response.
However, little is known about the capability of the immune cells of elderly individuals to dynamically counteract the oxidative stress.
Here, the response of the main lymphocyte subsets to the induced oxidative stress in semisupercentenarians (CENT), their offspring (OFF), elderly controls (CTRL), and young individuals (YO) was analyzed using flow cytometry.
The results showed that the ratio of the ROS levels between the induced and noninduced (I/NI) oxidative stress conditions was higher in CTRL and OFF than in CENT and YO, in almost all T, B, and NK subsets.
Moreover, the ratio of reduced glutathione levels between I/NI conditions was higher in OFF and CENT compared to the other groups in almost all the subsets.
Finally, we observed significant correlations between the response to the induced oxidative stress and the degree of methylation in specific genes on the oxidative stress pathway.
Globally, these data suggest that the capability to buffer dynamic changes in the oxidative environment could be a hallmark of longevity in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sizzano, Federico& Collino, Sebastiano& Cominetti, Ornella& Monti, Daniela& Garagnani, Paolo& Ostan, Rita…[et al.]. 2018. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sizzano, Federico…[et al.]. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sizzano, Federico& Collino, Sebastiano& Cominetti, Ornella& Monti, Daniela& Garagnani, Paolo& Ostan, Rita…[et al.]. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204129
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر