Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring
Joint Authors
Sizzano, Federico
Collino, Sebastiano
Cominetti, Ornella
Ostan, Rita
Palini, Alessio
Monti, Daniela
Garagnani, Paolo
Mari, Daniela
Franceschi, Claudio
Bacalini, Maria Giulia
Pirazzini, Chiara
Passarino, Giuseppe
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The production of reactive oxygen species (ROS) may promote immunosenescence if not counterbalanced by the antioxidant systems.
Cell membranes, proteins, and nucleic acids become the target of ROS and progressively lose their structure and functions.
This process could lead to an impairment of the immune response.
However, little is known about the capability of the immune cells of elderly individuals to dynamically counteract the oxidative stress.
Here, the response of the main lymphocyte subsets to the induced oxidative stress in semisupercentenarians (CENT), their offspring (OFF), elderly controls (CTRL), and young individuals (YO) was analyzed using flow cytometry.
The results showed that the ratio of the ROS levels between the induced and noninduced (I/NI) oxidative stress conditions was higher in CTRL and OFF than in CENT and YO, in almost all T, B, and NK subsets.
Moreover, the ratio of reduced glutathione levels between I/NI conditions was higher in OFF and CENT compared to the other groups in almost all the subsets.
Finally, we observed significant correlations between the response to the induced oxidative stress and the degree of methylation in specific genes on the oxidative stress pathway.
Globally, these data suggest that the capability to buffer dynamic changes in the oxidative environment could be a hallmark of longevity in humans.
American Psychological Association (APA)
Sizzano, Federico& Collino, Sebastiano& Cominetti, Ornella& Monti, Daniela& Garagnani, Paolo& Ostan, Rita…[et al.]. 2018. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
Modern Language Association (MLA)
Sizzano, Federico…[et al.]. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
American Medical Association (AMA)
Sizzano, Federico& Collino, Sebastiano& Cominetti, Ornella& Monti, Daniela& Garagnani, Paolo& Ostan, Rita…[et al.]. Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1204129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204129