tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate
المؤلفون المشاركون
Ventura-Gallegos, Jose Luis
Zentella-Dehesa, Alejandro
Luna-López, Armando
Gomez-Quiroz, Luis Enrique
Posadas-Rodríguez, Pedro
Posadas-Rodríguez, Natalia Esmeralda
González-Puertos, Viridiana Yazmín
Toledo-Pérez, Rafael
Konigsberg, Mina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health.
Therefore, these nutritional problems have become a concern to human healthspan and longevity.
The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death.
Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle.
Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis.
In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity.
Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect.
Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Posadas-Rodríguez, Pedro& Posadas-Rodríguez, Natalia Esmeralda& González-Puertos, Viridiana Yazmín& Toledo-Pérez, Rafael& Ventura-Gallegos, Jose Luis& Zentella-Dehesa, Alejandro…[et al.]. 2020. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Posadas-Rodríguez, Pedro…[et al.]. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Posadas-Rodríguez, Pedro& Posadas-Rodríguez, Natalia Esmeralda& González-Puertos, Viridiana Yazmín& Toledo-Pérez, Rafael& Ventura-Gallegos, Jose Luis& Zentella-Dehesa, Alejandro…[et al.]. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر