tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate
Joint Authors
Ventura-Gallegos, Jose Luis
Zentella-Dehesa, Alejandro
Luna-López, Armando
Gomez-Quiroz, Luis Enrique
Posadas-Rodríguez, Pedro
Posadas-Rodríguez, Natalia Esmeralda
González-Puertos, Viridiana Yazmín
Toledo-Pérez, Rafael
Konigsberg, Mina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health.
Therefore, these nutritional problems have become a concern to human healthspan and longevity.
The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death.
Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle.
Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis.
In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity.
Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect.
Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.
American Psychological Association (APA)
Posadas-Rodríguez, Pedro& Posadas-Rodríguez, Natalia Esmeralda& González-Puertos, Viridiana Yazmín& Toledo-Pérez, Rafael& Ventura-Gallegos, Jose Luis& Zentella-Dehesa, Alejandro…[et al.]. 2020. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
Modern Language Association (MLA)
Posadas-Rodríguez, Pedro…[et al.]. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
American Medical Association (AMA)
Posadas-Rodríguez, Pedro& Posadas-Rodríguez, Natalia Esmeralda& González-Puertos, Viridiana Yazmín& Toledo-Pérez, Rafael& Ventura-Gallegos, Jose Luis& Zentella-Dehesa, Alejandro…[et al.]. tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204159