Activation of Macrophages by Oligomeric Proteins of Different Size and Origin
المؤلفون المشاركون
Zvirbliene, Aurelija
Dalgediene, Indre
Lučiūnaitė, Asta
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host’s proteins.
Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions.
Data on the impact of protein structure during inflammation are evident; however, some separate steps of this process involving changes in macrophage phenotype are not fully understood.
Our aim was to investigate the phenotype of macrophages after activation with different oligomeric proteins and their IC.
We have used amyloid beta (Aβ1–42) that plays a role in neurodegenerative inflammation as a model of host-associated protein and three oligomeric viral antigens as pathogen-associated proteins.
Murine cell lines J774, BV-2, and macrophage primary cell culture were treated with oligomeric proteins and their IC.
After 48 h, expression of surface markers F4/80, CD68, CD86, and CD206 and secreted cytokines IL-10, IL-12, IL-23, and TNF-α was analysed.
Aβ1–42 oligomers stimulated expression of both inflammatory and anti-inflammatory molecules; however, fibrils induced less intense expression of markers investigated as compared to small and large oligomers.
Two out of three viral oligomeric proteins induced the inflammatory response of macrophages.
Data suggest that macrophage activation pattern depends on the origin, size, and structure of oligomeric proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dalgediene, Indre& Lučiūnaitė, Asta& Zvirbliene, Aurelija. 2018. Activation of Macrophages by Oligomeric Proteins of Different Size and Origin. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1204187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dalgediene, Indre…[et al.]. Activation of Macrophages by Oligomeric Proteins of Different Size and Origin. Mediators of Inflammation No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1204187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dalgediene, Indre& Lučiūnaitė, Asta& Zvirbliene, Aurelija. Activation of Macrophages by Oligomeric Proteins of Different Size and Origin. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1204187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر