Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice
المؤلفون المشاركون
Alhusayan, Rana M.
Aldahmash, Badr Abdullah
El-Nagar, Doaa M.
Rady, Ahmad
Ibrahim, Khalid Elfakki
Alkahtani, Saad
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The liver is the most vital organ that could be influenced by inducers of hypersensitivity such as ovalbumin.
The current study was carried out to explore the effects of butterbur (Petasites hybridus) extract on the ovalbumin-induced liver hypersensitivity in Swiss albino male mice.
Animals were divided into 4 groups, 1st group served as a control group, 2nd group treated with daily oral administration of 75 mg/kg of butterbur extract, 3rd group received single oral dose 100 mg/kg of ovalbumin to induce hypersensitivity, and 4th group treated with oral administration of butterbur extract one-day post to the hypersensitivity induction.
Ovalbumin induces a significant increase in the activity of liver enzymes and MDA and decreased the activity of CAT after the ovalbumin treatment.
Histopathological investigations revealed marked pathological alterations in liver tissues in the form of hyaline degeneration and fibrosis.
Additionally, heavy immune response indicated by immunostaining of MDA and TNF-α could be observed.
In contrast, posttreatment with butterbur extract after hypersensitivity induction resulted in a significant decrease of liver enzymes and oxidative stress and reduced the inflammation and fibrosis of liver tissues.
These results suggest that butterbur extract is considered as anti-inflammatory and antioxidant therapeutic herb for hypersensitivity treatment of liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alhusayan, Rana M.& Aldahmash, Badr Abdullah& El-Nagar, Doaa M.& Rady, Ahmad& Ibrahim, Khalid Elfakki& Alkahtani, Saad. 2020. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alhusayan, Rana M.…[et al.]. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alhusayan, Rana M.& Aldahmash, Badr Abdullah& El-Nagar, Doaa M.& Rady, Ahmad& Ibrahim, Khalid Elfakki& Alkahtani, Saad. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204192
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر